1L PEG-ASC (PLENVU®) improves high-quality overall and right colon cleansing vs sodium picosulfate + magnesium citrate1
Boston Bowel Preparation Scale
Ratings for 3 colon segments (right, left and transverse) on a 4-point scale:1
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High-quality cleansing = overall score of ≥82 (or 9 depending on study3) for whole colon or score 3 at segmental level.3
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Adequate-quality cleansing = overall score of ≥6 for whole colon or score ≥2 at segmental level.3
BBPS Score3,4
3 = Excellent
Entire mucosa of colon segment seen well with no residual staining, small fragments of stool or opaque liquid3
2 = Good
Minor amount of residual staining, small fragments of stool and/or opaque liquid, but mucosa of colon segment seen well3
1 = Poor
Portion of mucosa of colon segment seen, but other areas not well seen due to staining, residual stool and/or opaque liquid3
0 = Inadequate
Unprepared colon segment with mucosa not seen due to solid stool that cannot be cleared3
The final, published version of this article is available at https://karger.com/pjg/article-pdf/25/5/230/3438373/000485567.pdf
References: 1. Sharma P, et al. Endoscopy Int Open. 2020;08(5):E673-E683. 2. López-Jamar JME, et al. Endosc Int Open. 2023;11(8);E785-E793. 3. Hassan C, et al. Endosc Int Open. 2020;08(7):E928-E937. 4. Massinha, P, et al GE Port J Gastroenterol. 2018;25(5):230-235.
Study Design1
Study design
A systematic, prospective, single-centre Spanish study.
Aim
To evaluate the effectiveness and safety of 1L PEG-ASC (PLENVU®) versus sodium picosulfate + magnesium citrate in a real-world setting.
Patients
A total of 876 patients aged ≥18 years undergoing a screening or surveillance for colorectal cancer or diagnostic colonoscopy and follow-up of polypectomies were consecutively enrolled in a Spanish outpatient centre from July 2019 to October 2021.
Treatments
Patients were randomly assigned to one of two bowel cleansing preparations. Both groups received an afternoon-morning split dose regime:
- 1L PEG-ASC (PLENVU®)
- Sodium picosulfate + magnesium citrate.
Endpoints
Assessment of bowel cleansing success:
- Adequate bowel cleansing: total BBPS ≥6 with a partial BBPS ≥2 in each segment
- High-quality cleansing: total BBPS=8-9 and of the right colon as a partial BBPS=3.
Polyp detection rate in the overall colon.
Tolerability, measured as a subjective patient perception: good, regular or poor tolerability and difficulty in taking the preparation.
Safety considering the adverse events: vomiting, nausea and others, in addition to sodium and creatinine values post-treatment.
Endpoints were also evaluated in patients aged ≥65 years and in men versus women.
Statistical analysis
Kruskal-Wallis, Mann-Whitney U, and Chi-squared non-parametric tests were used.
Reference: 1. Pérez-Arellano E, et al. Rev Esp Enferm Dig. 2024;116(4):186-192.
BBPS, Boston Bowel Preparation Scale. SPMC, sodium picosulfate + magnesium citrate.
Prospective, systematic, single-centre Spanish study in a real-world setting; n=876.1
Graph adapted from paper.
Reference: 1. Pérez-Arellano E, et al. Rev Esp Enferm Dig. 2024;116(4):186-192.
